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KMID : 0387719950060020201
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Korean Journal of Blood Transfusion
1995 Volume.6 No. 2 p.201 ~ p.206
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A Family with D Phenotype Associated with Fatal hemolyti Disease of the Newborn
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김희정
주계원/한광수/심우섭/윤미숙/한복연/한규섭
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Abstract
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-D-is a very rare haplotype which determines D without C, c, E or e and exalted D activity. The extremely rare homozygote propositi(-D-/-D/_ are usually ascertained through their immune antibodies which react with red cells of all common Rh
phenotypes.
Authors experienced a woman with -D- phenotype for the first time in Korea. She had a history of abortion and intrauterine fetal death. She delivered a baby with severe hemolytic disease of the newborn at the third pregnancy. In spite of
intensive
medical interventions, the baby died of hydrops fetalis. An immune antibody to high incidence Rh antigen, namely anti-Hro was demonstrated in the woman's serum.
Family study revealed that all of the family and -D- gene complex and one of her sisters also was -D- homozygote. The sister also had anti-Hro in the serum.
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KEYWORD
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